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Faculty Profile Last Modified Time:    Contact Information Dr. Katja Michael ASSOCIATE PROFESSOR-CHEMISTRY     500 W. University Ave., El Paso, TX 79968     PHYSICAL SCIENCE BUILDING, Room No.: 201       915 7475240    faculty website    Synthesis of peptides and proteins with posttranslational modifications    Associated Profiles Professional Preparation Research and Expertise Publications Appointments Additional Information  Professional Preparation  Degree Major Institution Year  Ph.D.   Technical University of Munich 1996  B.A.   University of Frankfurt 1990  Research and Expertise Synthesis of peptides and proteins with posttranslational modifications   Synthesis of peptides and proteins with posttranslational modifications. My research focuses primarily on the synthetic method development for the construction of glycopeptides and glycoproteins.  Covalent glycosylation occurs in the vast majority of proteins that transit through the endoplasmatic reticulum in eukaryotic cells.  These include proteins that remain in the cell, and proteins secreted into the extracellular milieu.  The carbohydrate portions have essential biological or structural functions, which are generally not well understood.  The availability of structurally well-defined glycopeptides and glycoproteins is essential for the study of glycobiology and proteomics.  We have developed a photochemical method that allows for the convergent synthesis of complex N-glycopeptides under neutral reaction conditions by placing a photoreactive group in the side chain of asparagines.  We are now extending this research to the development of novel photoreactive solid supports with dual functionality, which enables us to synthesize C-terminally photoreactive peptides which can be derivatized by illumination with UV light in the presence of nucleophiles.  For example, in the presence of mercaptans, (glycol) peptide thioesters are generated, which serve as building blocks for the chemical synthesis of (glyco)proteins.  Publications   Category  All  Type AllOther Publications per page    1  2    Year Publication   Type 2007 Published Michael, K. "Convergent N-glycopeptide synthesis" in Frontiers in Modern Carbohydrate Chemistry p. 328 - 353 , Ed. Demchenko, A. American Chemical Society, 2007, Other 2007 Published T.J Hogenauer, Q. Wang, A.K. Sanki, A.J. Gammon, C.H.L. Chu, C.M. Kaneshiro, Y. Kajihara, K. MichaelOrg. Biomo. Chem. 2007, 5, 759-762. "Virtually epimerization-free synthesis of peptide-a-thioesters" Other 2006 Published Kaneshiro, C.M.; Michael, K. "A novel convergent synthesis of N-linked glycopeptides" Angew. Chem. Int. Ed.2006, 45, 1077-1081. Other 2005 Published   Simo,O.; Lee, V.P.; Davis, A.S.; Kreutz, C.; Gross,P.H.; Jones, R.P.; Michael, K. "Synthesis of glycosyl amino acids by light-induced coupling of photoreactive amino acids with glycosylamines and 1-C-aminomethyl glycosides, Carbohydrate Research2005, 340, 557-566 Other 2005 Published Simo, O.; Michael, K.; Yoshida, W.; Chertkov, V.A.; Gross, P.H. "Selective reductions of C-(4,6-O-benzylidene-b-d-glucopyranosyl nitromethane" Synthetic Communications2005,35, 1589-1599. Other  Appointments Duration Rank Department / School College / Office University / Company 2000-2006 Assistant Professor     University of Hawaii 1996-1999 Postdoctoral Fellow     University of California, San Diego  Additional Information Awards and Activities Victoria S. and Bradley L. Geist Foundation, 2001 ACS PRF Type G Award, 2003